Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord
XF Wu, WT Liu, YP Liu, ZJ Huang, YK Zhang, XJ Song - Pain, 2011 - Elsevier
Adenosine triphosphate–sensitive potassium (KATP) channels are suggested to be involved
in pathogenesis of neuropathic pain, but remain underinvestigated in primary afferents and
in the spinal cord. We examined alterations of KATP channels in rat spinal cord and tested
whether and how they could contribute to neuropathic pain. The results showed that protein
expression for KATP channel subunits SUR1, SUR2, and Kir6. 1, but not Kir6. 2, were
significantly downregulated and associated with thermal hyperalgesia and mechanical …
in pathogenesis of neuropathic pain, but remain underinvestigated in primary afferents and
in the spinal cord. We examined alterations of KATP channels in rat spinal cord and tested
whether and how they could contribute to neuropathic pain. The results showed that protein
expression for KATP channel subunits SUR1, SUR2, and Kir6. 1, but not Kir6. 2, were
significantly downregulated and associated with thermal hyperalgesia and mechanical …
