[HTML][HTML] Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that promotes angiogenesis,
metabolic reprogramming, and other critical aspects of cancer biology. The four-and-a-half
LIM domain (FHL) proteins are a family of LIM domain-only proteins implicated in
transcriptional regulation and suppression of tumor growth. Here we describe functional
interactions between the FHL proteins and HIF-1. FHL1–3 inhibit HIF-1 transcriptional
activity and HIF-1α transactivation domain function by oxygen-independent mechanisms …
metabolic reprogramming, and other critical aspects of cancer biology. The four-and-a-half
LIM domain (FHL) proteins are a family of LIM domain-only proteins implicated in
transcriptional regulation and suppression of tumor growth. Here we describe functional
interactions between the FHL proteins and HIF-1. FHL1–3 inhibit HIF-1 transcriptional
activity and HIF-1α transactivation domain function by oxygen-independent mechanisms …