[HTML][HTML] Depletion of the poly (C)-binding proteins αCP1 and αCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A …
SA Waggoner, GJ Johannes, SA Liebhaber - Journal of biological chemistry, 2009 - ASBMB
The α-globin poly (C)-binding proteins (αCPs) comprise an abundant and widely expressed
set of K-homolog domain RNA-binding proteins. αCPs regulate the expression of a number
of cellular and viral mRNAs at the levels of splicing, stability, and translation. Previous
surveys have identified 160 mRNAs that are bound by αCP in the human hematopoietic cell
line, K562. To explore the functions of these αCP/mRNA interactions, we identified mRNAs
whose levels are altered in K562 cells acutely depleted of the two major αCP proteins, αCP1 …
set of K-homolog domain RNA-binding proteins. αCPs regulate the expression of a number
of cellular and viral mRNAs at the levels of splicing, stability, and translation. Previous
surveys have identified 160 mRNAs that are bound by αCP in the human hematopoietic cell
line, K562. To explore the functions of these αCP/mRNA interactions, we identified mRNAs
whose levels are altered in K562 cells acutely depleted of the two major αCP proteins, αCP1 …