Interaction of poly (rC)-binding protein 2 with the 5′-terminal stem loop of the hepatitis C-virus genome
S Fukushi, M Okada, T Kageyama, FB Hoshino… - Virus research, 2001 - Elsevier
The 5′ noncoding region (NCR) of hepatitis C virus (HCV) contains an internal ribosome
entry site for translation initiation. Cellular proteins (eg La, polypyrimidine tract-binding
protein, and p25) that interact with HCV 5′ NCR have been implicated in facilitating
efficient internal initiation. The 5′ NCR may also contain RNA structures and specific RNA
sequences that interact with cellular proteins to promote RNA replication. UV crosslinking
experiments revealed a 43-kDa cellular protein (p43) also interacts with the HCV 5′ NCR …
entry site for translation initiation. Cellular proteins (eg La, polypyrimidine tract-binding
protein, and p25) that interact with HCV 5′ NCR have been implicated in facilitating
efficient internal initiation. The 5′ NCR may also contain RNA structures and specific RNA
sequences that interact with cellular proteins to promote RNA replication. UV crosslinking
experiments revealed a 43-kDa cellular protein (p43) also interacts with the HCV 5′ NCR …