[HTML][HTML] Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice
J Qin, D Van Buren, HS Huang, L Zhong… - Journal of biological …, 2010 - ASBMB
L3MBTL1, a paralogue of Drosophila tumor suppressor lethal (3) malignant brain tumor (l (3)
mbt), binds histones in a methylation state-dependent manner and contributes to higher
order chromatin structure and transcriptional repression. It is the founding member of a
family of MBT domain-containing proteins that has three members in Drosophila and nine in
mice and humans. Knockdown experiments in cell lines suggested that L3MBTL1 has non-
redundant roles in the suppression of oncogene expression. We generated a mutant mouse …
mbt), binds histones in a methylation state-dependent manner and contributes to higher
order chromatin structure and transcriptional repression. It is the founding member of a
family of MBT domain-containing proteins that has three members in Drosophila and nine in
mice and humans. Knockdown experiments in cell lines suggested that L3MBTL1 has non-
redundant roles in the suppression of oncogene expression. We generated a mutant mouse …
