[HTML][HTML] Inhibition of myoblast differentiation by tumor necrosis factor α is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor
J Alter, D Rozentzweig, E Bengal - Journal of biological chemistry, 2008 - ASBMB
The proinflammatory cytokine, TNFα plays a major role in muscle wasting occurring in
chronic diseases and muscular dystrophies. Among its other functions, TNFα perturbs
muscle regeneration by preventing satellite cell differentiation. In the present study, the role
of c-Jun N-terminal kinase (JNK), a mediator of TNFα, was investigated in differentiating
myoblast cell lines. Addition of TNFα to C2 myoblasts induced immediate and delayed
phases of JNK activity. The delayed phase is associated with myoblast proliferation …
chronic diseases and muscular dystrophies. Among its other functions, TNFα perturbs
muscle regeneration by preventing satellite cell differentiation. In the present study, the role
of c-Jun N-terminal kinase (JNK), a mediator of TNFα, was investigated in differentiating
myoblast cell lines. Addition of TNFα to C2 myoblasts induced immediate and delayed
phases of JNK activity. The delayed phase is associated with myoblast proliferation …