[HTML][HTML] Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis
K Kondoh, K Sunadome, E Nishida - Journal of biological chemistry, 2007 - ASBMB
Cross-talks among intracellular signaling pathways are important for the regulation of cell
fate decisions and cellular responses to extracellular signals. Both the Notch pathway and
the MAPK pathways play important roles in many biological processes, and the Notch
pathway has been shown to interact with the ERK-type MAPK pathway. However, its
interaction with the other MAPK pathways is unknown. Here we show that Notch signaling
activation in C2C12 cells suppresses the activity of p38 MAPK to inhibit myogenesis. Our …
fate decisions and cellular responses to extracellular signals. Both the Notch pathway and
the MAPK pathways play important roles in many biological processes, and the Notch
pathway has been shown to interact with the ERK-type MAPK pathway. However, its
interaction with the other MAPK pathways is unknown. Here we show that Notch signaling
activation in C2C12 cells suppresses the activity of p38 MAPK to inhibit myogenesis. Our …