Activation of the calcineurin-nuclear factor of activated T-cell signal transduction pathway in atrial fibrillation
CC Lin, JL Lin, CS Lin, MC Tsai, MJ Su, LP Lai… - Chest, 2004 - Elsevier
Study objectives: The calcineurin-nuclear factor of activated T-cell (NFAT) signal
transduction pathway regulates the expression of a plethora of genes in the myocardium.
Cytosolic calcium overloading occurs in atrial fibrillation (AF), and this fulfills the condition
needed for activation of this pathway. We therefore investigated the NFAT pathway in atrial
tissue in a porcine model of AF. Methods and results: AF was induced in eight adult pigs by
rapid atrial pacing. Investigations on the calcineurin and NFAT pathway were performed on …
transduction pathway regulates the expression of a plethora of genes in the myocardium.
Cytosolic calcium overloading occurs in atrial fibrillation (AF), and this fulfills the condition
needed for activation of this pathway. We therefore investigated the NFAT pathway in atrial
tissue in a porcine model of AF. Methods and results: AF was induced in eight adult pigs by
rapid atrial pacing. Investigations on the calcineurin and NFAT pathway were performed on …
