Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
Y Popov, E Patsenker, F Stickel, J Zaks, KR Bhaskar… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: The integrin αvβ6 promotes proliferation of specialized epithelia and
acts as a receptor for the activation of latent TGFβ1. We studied αvβ6 expression in
experimental and human liver fibrosis and the potential of its pharmacological inhibition for
treatment of hepatic fibrosis. METHODS: αvβ6 expression was studied by quantitative PCR
and immunohistochemistry in rats with cirrhosis due to bile duct ligation (BDL),
administration of thioacetamide (TAA), in Mdr2 (Abcb4)−/− mice with spontaneous biliary …
acts as a receptor for the activation of latent TGFβ1. We studied αvβ6 expression in
experimental and human liver fibrosis and the potential of its pharmacological inhibition for
treatment of hepatic fibrosis. METHODS: αvβ6 expression was studied by quantitative PCR
and immunohistochemistry in rats with cirrhosis due to bile duct ligation (BDL),
administration of thioacetamide (TAA), in Mdr2 (Abcb4)−/− mice with spontaneous biliary …
