Clearance of virus infection from the CNS
DE Griffin, T Metcalf - Current opinion in virology, 2011 - Elsevier
Viruses that cause encephalomyelitis infect neurons and recovery from infection requires
noncytolytic clearance of virus from the nervous system to avoid damaging these
irreplaceable cells. Several murine model systems of virus infection have been used to
identify clearance mechanisms. Quantitative analysis of Sindbis virus clearance over 6
months shows three phases: day 5–7, clearance of infectious virus, but continued presence
of viral RNA; day 8–60, decreasing levels of viral RNA; day 60–180, maintenance of viral …
noncytolytic clearance of virus from the nervous system to avoid damaging these
irreplaceable cells. Several murine model systems of virus infection have been used to
identify clearance mechanisms. Quantitative analysis of Sindbis virus clearance over 6
months shows three phases: day 5–7, clearance of infectious virus, but continued presence
of viral RNA; day 8–60, decreasing levels of viral RNA; day 60–180, maintenance of viral …