Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
HM Gao, F Zhang, H Zhou, W Kam… - Environmental health …, 2011 - ehp.niehs.nih.gov
Background Mechanisms whereby gene–environment interactions mediate chronic,
progressive neurodegenerative processes in Parkinson's disease (PD)—the second most
common neurodegenerative disease—remain elusive. Objective We created a two-hit
[neuroinflammation and mutant α-synuclein (α-syn) overexpression] animal model to
investigate mechanisms through which mutant α-syn and inflammation work in concert to
mediate chronic PD neurodegeneration. Methods We used an intraperitoneal injection of the …
progressive neurodegenerative processes in Parkinson's disease (PD)—the second most
common neurodegenerative disease—remain elusive. Objective We created a two-hit
[neuroinflammation and mutant α-synuclein (α-syn) overexpression] animal model to
investigate mechanisms through which mutant α-syn and inflammation work in concert to
mediate chronic PD neurodegeneration. Methods We used an intraperitoneal injection of the …