Iron overloading due to IE is a component of several disorders, including β-thalassemia [7]. β-thalassemia is a genetic disease characterized by reduced or absent synthesis of β-globin. Patients with the most severe form, β-thalassemia major or Cooley’s anemia, require lifelong blood transfusions whereas those with a milder form, β-thalassemia intermedia, may be able to survive with limited or no transfusions [9]. The defect in β-globin synthesis generates chronic anemia, which exacerbates IE and promotes extra medullary hematopoiesis, splenomegaly and iron