[HTML][HTML] Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1
Y Zeng, N Tao, KN Chung, JE Heuser… - Journal of Biological …, 2003 - ASBMB
The scavenger receptor CD36 binds a diverse array of ligands, including thrombospondin-1,
oxidized low density lipoprotein (OxLDL), fatty acids, anionic phospholipids, and apoptotic
cells. CD36 has been reported to be present in lipid rafts/caveolae, but little is known about
the membrane trafficking of this protein at baseline or following ligand binding. Here, we
determined that expression of CD36 in Chinese hamster ovary (CHO) cells and endogenous
expression of CD36 in C32 cells led to a homogeneous distribution of the protein on the …
oxidized low density lipoprotein (OxLDL), fatty acids, anionic phospholipids, and apoptotic
cells. CD36 has been reported to be present in lipid rafts/caveolae, but little is known about
the membrane trafficking of this protein at baseline or following ligand binding. Here, we
determined that expression of CD36 in Chinese hamster ovary (CHO) cells and endogenous
expression of CD36 in C32 cells led to a homogeneous distribution of the protein on the …