[HTML][HTML] Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29
M Kwiecinski, N Elfimova, A Noetel, U Töx… - Laboratory …, 2012 - Elsevier
MicroRNAs are short noncoding, endogenous RNA species that posttranscriptionally inhibit
gene expression by targeting the untranslated region (UTR) of mRNAs. Recently, it was
shown that miR-29 inhibits expression of extracellular matrix proteins such as collagens,
suggesting an antifibrotic function of miR-29. In the present study, we now investigated the
role of miR-29 in profibrogenic growth factor expression as a further central mechanism of
fibrosis. Screening of databases revealed putative miR-29 target sequences in the mRNA of …
gene expression by targeting the untranslated region (UTR) of mRNAs. Recently, it was
shown that miR-29 inhibits expression of extracellular matrix proteins such as collagens,
suggesting an antifibrotic function of miR-29. In the present study, we now investigated the
role of miR-29 in profibrogenic growth factor expression as a further central mechanism of
fibrosis. Screening of databases revealed putative miR-29 target sequences in the mRNA of …