[HTML][HTML] Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor
C Sanchez, I Sanchez, JAA Demmers… - Molecular & cellular …, 2007 - ASBMB
Ring1B/Rnf2 is a RING finger protein member of the Polycomb group (PcG) of proteins,
which form chromatin-modifying complexes essential for embryonic development and stem
cell renewal and which are commonly deregulated in cancer. Ring1B/Rnf2 is a ubiquitin E3
ligase that catalyzes the monoubiquitylation of the histone H2A, one of the histone
modifications needed for the transcriptional repression activity of the PcG of proteins.
Ring1B/Rnf2 was shown to be part of two complexes, the PRC1 PcG complex and the E2F6 …
which form chromatin-modifying complexes essential for embryonic development and stem
cell renewal and which are commonly deregulated in cancer. Ring1B/Rnf2 is a ubiquitin E3
ligase that catalyzes the monoubiquitylation of the histone H2A, one of the histone
modifications needed for the transcriptional repression activity of the PcG of proteins.
Ring1B/Rnf2 was shown to be part of two complexes, the PRC1 PcG complex and the E2F6 …