[HTML][HTML] Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary …
Sustained expression of the histone demethylase, KDM2B (Ndy1/FBXL10/JHDM1B),
bypasses cellular senescence in primary mouse embryonic fibroblasts (MEFs). Here, we
show that KDM2B is a conserved regulator of lifespan in multiple primary cell types and
defines a program in which this chromatin-modifying enzyme counteracts the senescence-
associated down-regulation of the EZH2 histone methyltransferase. Senescence in MEFs
epigenetically silences KDM2B and induces the tumor suppressor miRNAs let-7b and miR …
bypasses cellular senescence in primary mouse embryonic fibroblasts (MEFs). Here, we
show that KDM2B is a conserved regulator of lifespan in multiple primary cell types and
defines a program in which this chromatin-modifying enzyme counteracts the senescence-
associated down-regulation of the EZH2 histone methyltransferase. Senescence in MEFs
epigenetically silences KDM2B and induces the tumor suppressor miRNAs let-7b and miR …