Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction
Metabolic syndrome (MetS) may have increased cortisol (F) production caused by 11β-
hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis
dysregulation. F is then mainly metabolized by liver reductases into inactive
tetrahydrometabolites (THMs). We measured THM levels in patients with or without MetS
and evaluate the correlation between THMs and anthropometric and biochemical
parameters. We recruited 221 subjects, of whom 130 had MetS by ATP III. We evaluated F …
hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis
dysregulation. F is then mainly metabolized by liver reductases into inactive
tetrahydrometabolites (THMs). We measured THM levels in patients with or without MetS
and evaluate the correlation between THMs and anthropometric and biochemical
parameters. We recruited 221 subjects, of whom 130 had MetS by ATP III. We evaluated F …
