Toxic epidermal necrolysis
FA Pereira, AV Mudgil, DM Rosmarin - Journal of the American Academy of …, 2007 - Elsevier
Toxic epidermal necrolysis (TEN) is an unpredictable, life-threatening drug reaction
associated with a 30% mortality. Massive keratinocyte apoptosis is the hallmark of TEN.
Cytotoxic T lymphocytes appear to be the main effector cells and there is experimental
evidence for involvement of both the Fas-Fas ligand and perforin/granzyme pathways.
Optimal treatment for these patients remains to be clarified. Discontinuation of the offending
drug and prompt referral to a burn unit are generally agreed upon steps. Beyond that …
associated with a 30% mortality. Massive keratinocyte apoptosis is the hallmark of TEN.
Cytotoxic T lymphocytes appear to be the main effector cells and there is experimental
evidence for involvement of both the Fas-Fas ligand and perforin/granzyme pathways.
Optimal treatment for these patients remains to be clarified. Discontinuation of the offending
drug and prompt referral to a burn unit are generally agreed upon steps. Beyond that …
