Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
G Zollner, P Fickert, A Fuchsbichler, D Silbert… - Journal of …, 2003 - Elsevier
Background/Aims: Adaptive changes in transporter expression in liver and kidney provide
alternative excretory pathways for biliary constituents during cholestasis and may thus
attenuate liver injury. Whether adaptive changes in ATP-binding cassette (ABC) transporter
expression are stimulated by bile acids and their nuclear receptor FXR is unknown.
Methods: Hepatic, renal and intestinal ABC transporter expression was compared in cholic
acid (CA)-and ursodeoxycholic acid (UDCA)-fed wild-type (FXR+/+) and FXR knock-out …
alternative excretory pathways for biliary constituents during cholestasis and may thus
attenuate liver injury. Whether adaptive changes in ATP-binding cassette (ABC) transporter
expression are stimulated by bile acids and their nuclear receptor FXR is unknown.
Methods: Hepatic, renal and intestinal ABC transporter expression was compared in cholic
acid (CA)-and ursodeoxycholic acid (UDCA)-fed wild-type (FXR+/+) and FXR knock-out …
