[HTML][HTML] Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle
JT Brozinick, MJ Birnbaum - Journal of Biological Chemistry, 1998 - ASBMB
Insulin and muscle contraction potently stimulate glucose uptake in mammalian skeletal
muscle. Studies in muscle and adipose tissue have shown that insulin induces its receptor-
dependent phosphorylation of insulin receptor substrates 1 and 2, which leads to activation
of polyphosphatidylinositol (PI) 3′-kinase. In contrast, muscle contraction stimulates
glucose transport via a mechanism that is independent of insulin, but the two pathways may
converge downstream at the level of stimulation of GLUT4 translocation. In the present …
muscle. Studies in muscle and adipose tissue have shown that insulin induces its receptor-
dependent phosphorylation of insulin receptor substrates 1 and 2, which leads to activation
of polyphosphatidylinositol (PI) 3′-kinase. In contrast, muscle contraction stimulates
glucose transport via a mechanism that is independent of insulin, but the two pathways may
converge downstream at the level of stimulation of GLUT4 translocation. In the present …