Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus
CL Bowlus, J Ahn, T Chu, JR Gruen - Cellular immunology, 1999 - Elsevier
Antigen presentation by cortical thymic epithelial cells (cTEC) during the positive selection of
T cells has been shown to differ from that of other antigen-presenting cells. In the case of
MHC class II presentation, cathepsin L as opposed to cathepsin S is responsible at least in
part for the degradation of invariant chain. Other proteases, however, must be involved. We
have identified a putative serine protease that is specifically expressed in the thymus.
Encoded within the class I major histocompatibility complex (MHC) region, this gene has …
T cells has been shown to differ from that of other antigen-presenting cells. In the case of
MHC class II presentation, cathepsin L as opposed to cathepsin S is responsible at least in
part for the degradation of invariant chain. Other proteases, however, must be involved. We
have identified a putative serine protease that is specifically expressed in the thymus.
Encoded within the class I major histocompatibility complex (MHC) region, this gene has …