Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome
K Ueki, T Kadowaki, CR Kahn - Hepatology research, 2005 - Elsevier
Insulin resistance, obesity, diabetes, dyslipidemia and nonalcoholic fatty liver are
components of the metabolic syndrome, a disease complex that is increasing at epidemic
rates in westernized countries. Although proinflammatory cytokines have been suggested to
contribute to the development of these disorders, the molecular mechanism of the
development of this syndrome is poorly understood. In this study, we show that expression of
suppressor of cytokine signaling SOCS-1 and SOCS-3 is increased in livers of obese insulin …
components of the metabolic syndrome, a disease complex that is increasing at epidemic
rates in westernized countries. Although proinflammatory cytokines have been suggested to
contribute to the development of these disorders, the molecular mechanism of the
development of this syndrome is poorly understood. In this study, we show that expression of
suppressor of cytokine signaling SOCS-1 and SOCS-3 is increased in livers of obese insulin …