Eukaryotic glycogen synthase activity is regulated by reversible phosphorylation at multiple
sites. Of the two GS isoforms found in mammals, the muscle enzyme (muscle glycogen
synthase) has received more attention and the relative importance of every known
phosphorylation site in the control of its activity and intracellular distribution has been
previously addressed. We have analyzed the impact of the dephosphorylation at the
homologous sites of the glycogen synthase liver (LGS) isoform. Serine residues at these …