Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation
JP Mauldin, S Srinivasan, A Mulya, A Gebre… - Journal of biological …, 2006 - ASBMB
Atherosclerosis development is accelerated severalfold in patients with Type 2 diabetes. In
the initial stages of disease, monocytes transmigrate into the subendothelial space and
differentiate into foam cells. Scavenger receptors and ATP binding cassette (ABC)
Transporters play an important role in foam cell formation as they regulate the influx and
efflux of oxidized lipids. Here, we show that peritoneal macrophages isolated from Type 2
diabetic db/db mice have decreased expression of the ABC transporter ABCG1 and …
the initial stages of disease, monocytes transmigrate into the subendothelial space and
differentiate into foam cells. Scavenger receptors and ATP binding cassette (ABC)
Transporters play an important role in foam cell formation as they regulate the influx and
efflux of oxidized lipids. Here, we show that peritoneal macrophages isolated from Type 2
diabetic db/db mice have decreased expression of the ABC transporter ABCG1 and …
