Restricting food intake to 50 to 70% of that eaten by ad lib-fed rats and mice markedly
increases longevity, retards age-associated physiological deterioration, and delays and, in
some cases, prevents age-associated diseases. These actions are due to the reduced
intake of calories, and thus the phenomenon has been called the antiaging action of caloric
restriction (CR). This article focuses on the possible biological mechanisms underlying the
antiaging action. The following three proposed mechanisms are considered in depth: 1) …