Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma
M Chuma, M Sakamoto, J Yasuda, G Fujii… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: The molecular basis of the metastasis of hepatocellular carcinoma
(HCC) is not fully understood. The aim of this study was to elucidate the crucial genes
involved in metastasis of HCC. METHODS: We compared expression profiles among highly
metastatic HCC cell lines and non-metastatic HCC cell lines by using oligonucleotide array
to identify genes associated with metastasis. We further investigated the effect of identified
gene on cell motility and metastasis in vitro and in vivo. Finally, we examined …
(HCC) is not fully understood. The aim of this study was to elucidate the crucial genes
involved in metastasis of HCC. METHODS: We compared expression profiles among highly
metastatic HCC cell lines and non-metastatic HCC cell lines by using oligonucleotide array
to identify genes associated with metastasis. We further investigated the effect of identified
gene on cell motility and metastasis in vitro and in vivo. Finally, we examined …
