Lymphoma in common variable immunodeficiency: interplay between immune dysregulation, infection and genetics
I Chua, I Quinti, B Grimbacher - Current opinion in hematology, 2008 - journals.lww.com
I Chua, I Quinti, B Grimbacher
Current opinion in hematology, 2008•journals.lww.comThere are several reasons for an increased risk of lymphoma in common variable
immunodeficiency patients. These include genetics, immune dysregulation, radiosensitivity
and chronic infections such as Helicobacter pylori, human herpes virus type 8 and
cytomegalovirus. Chronic infections may enhance the development of lymphoma in an
antigen specific manner. The interaction between chronic infections and the development of
lymphoma is still unclear but studies to clarify this may lead to prevention measures and …
immunodeficiency patients. These include genetics, immune dysregulation, radiosensitivity
and chronic infections such as Helicobacter pylori, human herpes virus type 8 and
cytomegalovirus. Chronic infections may enhance the development of lymphoma in an
antigen specific manner. The interaction between chronic infections and the development of
lymphoma is still unclear but studies to clarify this may lead to prevention measures and …
Summary
There are several reasons for an increased risk of lymphoma in common variable immunodeficiency patients. These include genetics, immune dysregulation, radiosensitivity and chronic infections such as Helicobacter pylori, human herpes virus type 8 and cytomegalovirus. Chronic infections may enhance the development of lymphoma in an antigen specific manner. The interaction between chronic infections and the development of lymphoma is still unclear but studies to clarify this may lead to prevention measures and lymphoma reduction strategies.
Lippincott Williams & Wilkins