Cryptococcus neoformans is an encapsulated pathogenic fungus. The cryptococcal capsule
is composed of polysaccharides and is necessary for virulence. It has been previously
reported that glucuronoxylomannan (GXM), the major capsular component, is synthesized in
cytoplasmic compartments and transported to the extracellular space in vesicles, but
knowledge on the organelles involved in polysaccharide synthesis and traffic is extremely
limited. In this paper we report the GXM distribution in C. neoformans cells sectioned by …