Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Cα regulates endocytosis and association with adaptor …
S Ranganathan, CX Liu, MM Migliorini… - Journal of Biological …, 2004 - ASBMB
The low density lipoprotein receptor-related protein (LRP) is a large receptor that
participates in endocytosis, signaling pathways, and phagocytosis of necrotic cells.
Mechanisms that direct LRP to function in these distinct pathways likely involve its
association with distinct cytoplasmic adaptor proteins. We tested the hypothesis that the
association of various adaptor proteins with the LRP cytoplasmic domain is modulated by its
phosphorylation state. Phosphoamino acid analysis of metabolically labeled LRP revealed …
participates in endocytosis, signaling pathways, and phagocytosis of necrotic cells.
Mechanisms that direct LRP to function in these distinct pathways likely involve its
association with distinct cytoplasmic adaptor proteins. We tested the hypothesis that the
association of various adaptor proteins with the LRP cytoplasmic domain is modulated by its
phosphorylation state. Phosphoamino acid analysis of metabolically labeled LRP revealed …
