[HTML][HTML] Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice
D Terwel, R Lasrado, J Snauwaert… - Journal of Biological …, 2005 - ASBMB
Protein tau-3R/4R isoform ratio and phosphorylation regulates binding to microtubules and,
when disturbed by aging or mutations, results in diverse tauopathies and in
neurodegeneration. The underlying mechanisms were studied here in three transgenic
mouse strains with identical genetic background, all expressing the tau-4R/2N isoform
driven specifically in neurons by the thy1 gene promoter. Two strains, expressing human tau-
4R/2N or mutant tau-4R/2N-P301L at similar, moderate levels, developed very different …
when disturbed by aging or mutations, results in diverse tauopathies and in
neurodegeneration. The underlying mechanisms were studied here in three transgenic
mouse strains with identical genetic background, all expressing the tau-4R/2N isoform
driven specifically in neurons by the thy1 gene promoter. Two strains, expressing human tau-
4R/2N or mutant tau-4R/2N-P301L at similar, moderate levels, developed very different …