The regulation of hepatic glucose metabolism is important in glucose homeostasis, and liver
glucokinase (LGK) plays a central role in this process. Hepatic glucokinase expression is
known to be regulated by insulin. Recently it has been suggested that sterol regulatory
element binding protein-1c (SREBP-1c) mediates the action of insulin on LGK transcription;
however, the precise mechanism is not, to date, well known. In the present study, we
identified two functional SREBP-1c response elements, SREa and SREb, in the rat LGK …