Cloning of the γ chain of the human IL-2 receptor
T Takeshita, H Asao, K Ohtani, N Ishii, S Kumaki… - Science, 1992 - science.org
T Takeshita, H Asao, K Ohtani, N Ishii, S Kumaki, N Tanaka, H Munakata, M Nakamura…
Science, 1992•science.orgA third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a
complementary DNA clone encoding this member of the cytokine receptor family was
isolated. The γ chain is necessary for the formation of the high-and intermediate-affinity
receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R
on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is
present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable …
complementary DNA clone encoding this member of the cytokine receptor family was
isolated. The γ chain is necessary for the formation of the high-and intermediate-affinity
receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R
on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is
present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable …
A third subunit, the γ chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The γ chain is necessary for the formation of the high- and intermediate-affinity receptors, which consist of αβγ heterotrimers and βγ heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the γ chain is present; α and β are insufficient for internalization. Thus, the γ chain is an indispensable component of the functional IL-2R.
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