[HTML][HTML] Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase …
KA Martin, SS Schalm, A Romanelli, KL Keon… - Journal of Biological …, 2001 - ASBMB
Ribosomal S6 kinase 2 (S6K2) is a recently identified serine/threonine protein kinase that
phosphorylates the 40 S ribosomal protein S6 in vitro. S6K2 is highly homologous to S6K1
in the core kinase and linker regulatory domains but differs from S6K1 in the N-and C-
terminal regions and is differently localized primarily to the nucleus because of a C-terminal
nuclear localization signal unique to S6K2. We have recently demonstrated that S6K2 is
regulated similarly to S6K1 by the mammalian target of rapamycin pathway and by multiple …
phosphorylates the 40 S ribosomal protein S6 in vitro. S6K2 is highly homologous to S6K1
in the core kinase and linker regulatory domains but differs from S6K1 in the N-and C-
terminal regions and is differently localized primarily to the nucleus because of a C-terminal
nuclear localization signal unique to S6K2. We have recently demonstrated that S6K2 is
regulated similarly to S6K1 by the mammalian target of rapamycin pathway and by multiple …