Analysis of microsatellite instability and loss of heterozygosity in uterine endometrial adenocarcinoma
T Toda, H Oku, NM Khaskhely, H Moromizato… - Cancer genetics and …, 2001 - Elsevier
Microsatellite instability (MSI) and loss of heterozygosity (LOH) were examined in 60 cases
of uterine endometrial adenocarcinoma, using 13 microsatellite markers. In non-Smad-
related regions, MSI and LOH were noted in 13 of 60 (21.7%) and in 20 of 60 (33.3%) cases,
respectively. Genetic alternation of TGF-β RII was noted in 1 of 60 cases (1.7%). The
frequency of MSI and LOH was highest in Stages III and IV, respectively. Cases with G2
carcinoma showed the highest frequency, but LOH frequency did not differ among G1, G2 …
of uterine endometrial adenocarcinoma, using 13 microsatellite markers. In non-Smad-
related regions, MSI and LOH were noted in 13 of 60 (21.7%) and in 20 of 60 (33.3%) cases,
respectively. Genetic alternation of TGF-β RII was noted in 1 of 60 cases (1.7%). The
frequency of MSI and LOH was highest in Stages III and IV, respectively. Cases with G2
carcinoma showed the highest frequency, but LOH frequency did not differ among G1, G2 …
