Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
AP Gilmore, AJ Valentijn, P Wang, AM Ranger… - Journal of Biological …, 2002 - ASBMB
Novel cancer chemotherapeutics are required to induce apoptosis by activating pro-
apoptotic proteins. Both epidermal growth factor (EGF) and insulin-like growth factor (IGF)
provide potent survival stimuli in many epithelia, and activation of their receptors is
commonly observed in solid human tumors. Here we demonstrate that blockade of the EGF
receptor by a new drug in phase III clinical trails for cancer, ZD1839, potently induces
apoptosis in mammary epithelial cell lines and primary cultures, as well as in a primary …
apoptotic proteins. Both epidermal growth factor (EGF) and insulin-like growth factor (IGF)
provide potent survival stimuli in many epithelia, and activation of their receptors is
commonly observed in solid human tumors. Here we demonstrate that blockade of the EGF
receptor by a new drug in phase III clinical trails for cancer, ZD1839, potently induces
apoptosis in mammary epithelial cell lines and primary cultures, as well as in a primary …
