[HTML][HTML] Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization
MJ Orsini, JL Parent, SJ Mundell, JL Benovic - Journal of Biological …, 1999 - ASBMB
The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for
entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization
as well as internalization in response to stimulation with phorbol esters and ligand (SDF-1α).
We investigated the trafficking of this receptor, and we attempted to define the residues of
CXCR4 that were critical for receptor internalization. In both COS-1 and HEK-293 cells
transiently overexpressing CXCR4, SDF-1α and phorbol esters (PMA) promoted rapid …
entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization
as well as internalization in response to stimulation with phorbol esters and ligand (SDF-1α).
We investigated the trafficking of this receptor, and we attempted to define the residues of
CXCR4 that were critical for receptor internalization. In both COS-1 and HEK-293 cells
transiently overexpressing CXCR4, SDF-1α and phorbol esters (PMA) promoted rapid …