[HTML][HTML] Gαq-coupled Receptor Internalization Specifically Induced by Gαq Signaling: REGULATION BY EBP50
MD Rochdi, JL Parent - Journal of Biological Chemistry, 2003 - ASBMB
In the present report, we investigated the effect of ezrin-radixin-moesin-binding
phosphoprotein 50 (EBP50) expression on the agonist-induced internalization of the
thromboxane A 2 β receptor (TPβ receptor). Interestingly, we found that EBP50 almost
completely blocked TPβ receptor internalization, which could not be reversed by
overexpression of G protein-coupled receptor (GPCR) kinases and arrestins. Because we
recently demonstrated that EBP50 can bind to and inhibit Gα q, we next studied whether Gα …
phosphoprotein 50 (EBP50) expression on the agonist-induced internalization of the
thromboxane A 2 β receptor (TPβ receptor). Interestingly, we found that EBP50 almost
completely blocked TPβ receptor internalization, which could not be reversed by
overexpression of G protein-coupled receptor (GPCR) kinases and arrestins. Because we
recently demonstrated that EBP50 can bind to and inhibit Gα q, we next studied whether Gα …