G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization
K Peppel, I Boekhoff, P McDonald, H Breer… - Journal of Biological …, 1997 - ASBMB
G protein-coupled receptor kinases (GRKs) 2 and 3 (β-adrenergic receptor kinases 1 and 2
(βARK1 and-2)) mediate the agonist-dependent phosphorylation and uncoupling of many G
protein-coupled receptors. These two members of the GRK family share a high degree of
sequence homology and show overlapping patterns of substrate specificity in vitro. To define
their physiological roles in vivo we have generated mice that carry targeted disruption of
these genes. In contrast to GRK2-deficient mice, which die in utero (Jaber, M., Koch, WJ …
(βARK1 and-2)) mediate the agonist-dependent phosphorylation and uncoupling of many G
protein-coupled receptors. These two members of the GRK family share a high degree of
sequence homology and show overlapping patterns of substrate specificity in vitro. To define
their physiological roles in vivo we have generated mice that carry targeted disruption of
these genes. In contrast to GRK2-deficient mice, which die in utero (Jaber, M., Koch, WJ …
