[HTML][HTML] Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor …
D Bhandari, JA Trejo, JL Benovic… - Journal of Biological …, 2007 - ASBMB
The chemokine receptor CXCR4 is rapidly targeted for lysosomal degradation by the E3
ubiquitin ligase atrophin-interacting protein 4 (AIP4). Although it is known that AIP4 mediates
ubiquitination and degradation of CXCR4 and that perturbations in these events contribute
to disease, the mechanisms mediating AIP4-dependent regulation of CXCR4 degradation
remain poorly understood. Here we show that AIP4 directly interacts with the amino-terminal
half of nonvisual arrestin-2 via its WW domains. We show that depletion of arrestin-2 by …
ubiquitin ligase atrophin-interacting protein 4 (AIP4). Although it is known that AIP4 mediates
ubiquitination and degradation of CXCR4 and that perturbations in these events contribute
to disease, the mechanisms mediating AIP4-dependent regulation of CXCR4 degradation
remain poorly understood. Here we show that AIP4 directly interacts with the amino-terminal
half of nonvisual arrestin-2 via its WW domains. We show that depletion of arrestin-2 by …