[HTML][HTML] Microvascular hyperpermeability in caveolin-1 (−/−) knock-out mice: Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal …
W Schubert, PG Frank, SE Woodman, H Hyogo… - Journal of Biological …, 2002 - ASBMB
Microvascular permeability is mediated by (i) the caveolar transcytosis of molecules across
endothelial cells and (ii) the paracellular movement of ions and nutrients. Recently, we
derived Cav-1 (−/−) knock-out mice using standard homologous recombination techniques.
These mice are viable but show a loss of endothelial cell caveolae and striking defects in
caveolae-mediated endocytosis. Thus, a compensatory mechanism must be operating in
these mice. One possible compensatory response would be an increase in the paracellular …
endothelial cells and (ii) the paracellular movement of ions and nutrients. Recently, we
derived Cav-1 (−/−) knock-out mice using standard homologous recombination techniques.
These mice are viable but show a loss of endothelial cell caveolae and striking defects in
caveolae-mediated endocytosis. Thus, a compensatory mechanism must be operating in
these mice. One possible compensatory response would be an increase in the paracellular …
