Evolutionary Duplication of a Hepatic Control Region in the Human Apolipoprotein E Gene Locus: IDENTIFICATION OF A SECOND REGION THAT CONFERS HIGH …
CM Allan, D Walker, JM Taylor - Journal of Biological Chemistry, 1995 - ASBMB
We have identified a second hepatic control region (HCR-2) in the human apolipoprotein
(apo) E gene locus that confers liver expression of the human apoE gene in transgenic mice.
This HCR-2 sequence is located 27 kilobases downstream of the apoE gene and 10
kilobases downstream of the previously described liver-specific enhancer (HCR-1).
Nucleotide sequence analysis of the HCR-2 region revealed a sequence that shares 85%
identity to the functional 319-base pair domain of HCR-1. To test its activity, transgenic mice …
(apo) E gene locus that confers liver expression of the human apoE gene in transgenic mice.
This HCR-2 sequence is located 27 kilobases downstream of the apoE gene and 10
kilobases downstream of the previously described liver-specific enhancer (HCR-1).
Nucleotide sequence analysis of the HCR-2 region revealed a sequence that shares 85%
identity to the functional 319-base pair domain of HCR-1. To test its activity, transgenic mice …
