Activation of human serum complement with allergens: I. Generation of C3a, C4a, and C5a and induction of human neutrophil aggregation
S Nagata, MM Glovsky - Journal of allergy and clinical immunology, 1987 - Elsevier
To understand the relevance of allergens in generation of C3a, C4a, and C5a in normal
human serum, we studied extracts of several allergens (house dust, house dust mite,
Aspergillus fumigatus, and perennial ryegrass). Known complement activators zymosan and
endotoxin were used as controls. Generation of C3a, C4a, and C5a (determined by
radioimmunoassays) occurred with extracts of house dust and Aspergillus more than with
house dust mite and ryegrass. Anaphylatoxins were produced both in dose and time …
human serum, we studied extracts of several allergens (house dust, house dust mite,
Aspergillus fumigatus, and perennial ryegrass). Known complement activators zymosan and
endotoxin were used as controls. Generation of C3a, C4a, and C5a (determined by
radioimmunoassays) occurred with extracts of house dust and Aspergillus more than with
house dust mite and ryegrass. Anaphylatoxins were produced both in dose and time …