Autoantibodies to collagens in Japanese patients with ankylosing spondylitis.
Y Tani, H Sato, S Hukuda - Clinical and experimental rheumatology, 1997 - europepmc.org
Y Tani, H Sato, S Hukuda
Clinical and experimental rheumatology, 1997•europepmc.orgObjective We measured antibody levels against human type I, II, III and IV collagens in
Japanese patients with ankylosing spondylitis (AS) by enzyme linked immunosorbent assay
(ELISA). Results Significant elevations of antibodies against type II (IgG and IgA classes)
and type IV (IgA class) collagens were observed in AS patients, whilst there was no
significant elevation of any antibody class against type I or III collagen when compared to
controls. Conclusion These findings indicate that AS patients have immune responses to …
Japanese patients with ankylosing spondylitis (AS) by enzyme linked immunosorbent assay
(ELISA). Results Significant elevations of antibodies against type II (IgG and IgA classes)
and type IV (IgA class) collagens were observed in AS patients, whilst there was no
significant elevation of any antibody class against type I or III collagen when compared to
controls. Conclusion These findings indicate that AS patients have immune responses to …
Objective
We measured antibody levels against human type I, II, III and IV collagens in Japanese patients with ankylosing spondylitis (AS) by enzyme linked immunosorbent assay (ELISA).
Results
Significant elevations of antibodies against type II (IgG and IgA classes) and type IV (IgA class) collagens were observed in AS patients, whilst there was no significant elevation of any antibody class against type I or III collagen when compared to controls.
Conclusion
These findings indicate that AS patients have immune responses to type II and IV collagens, which may be responsible for sustaining the characteristic local inflammations in AS.
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