Molecular genetic profiling of Gleason grade 4/5 prostate cancers compared to benign prostatic hyperplasia
TA Stamey, JA Warrington, MC Caldwell, Z Chen… - The Journal of …, 2001 - Elsevier
PURPOSE: Because Gleason grade 4/5 cancer is the primary cause of failure to cure
prostate cancer, we examined the molecular profiles of this high grade cancer in search of
potentially new therapeutic interventions as well as better serum markers than prostate
specific antigen. MATERIALS AND METHODS: We compared the gene expressions in fresh
frozen tissues from 9 men with Gleason grade 4/5 cancer to 8 men with benign prostatic
hyperplasia (BPH) treated with radical retropubic prostatectomy. Labeled complementary …
prostate cancer, we examined the molecular profiles of this high grade cancer in search of
potentially new therapeutic interventions as well as better serum markers than prostate
specific antigen. MATERIALS AND METHODS: We compared the gene expressions in fresh
frozen tissues from 9 men with Gleason grade 4/5 cancer to 8 men with benign prostatic
hyperplasia (BPH) treated with radical retropubic prostatectomy. Labeled complementary …