Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22
BA Hosler, T Siddique, PC Sapp, W Sailor, MC Huang… - Jama, 2000 - jamanetwork.com
ContextOccasionally, 2 or more major neurodegenerative diseases arise simultaneously. An
understanding of the genetic bases of combined disorders, such as amyotrophic lateral
sclerosis (ALS) with frontotemporal dementia (FTD), will likely provide insight into
mechanisms of these and related neurodegenerative diseases. ObjectiveTo identify loci that
contain genes whose defects cause ALS. DesignA genome-wide linkage analysis of 2 data
sets from an ongoing study begun in the mid-1980s at 4 university research centers …
understanding of the genetic bases of combined disorders, such as amyotrophic lateral
sclerosis (ALS) with frontotemporal dementia (FTD), will likely provide insight into
mechanisms of these and related neurodegenerative diseases. ObjectiveTo identify loci that
contain genes whose defects cause ALS. DesignA genome-wide linkage analysis of 2 data
sets from an ongoing study begun in the mid-1980s at 4 university research centers …