No association with the neuregulin 1 haplotype to Japanese schizophrenia
N Iwata, T Suzuki, M Ikeda, T Kitajima… - Molecular …, 2004 - nature.com
N Iwata, T Suzuki, M Ikeda, T Kitajima, Y Yamanouchi, T Inada, N Ozaki
Molecular psychiatry, 2004•nature.comSIR—Schizophrenia is a complex genetic disorder and has heritability of around 80%. The
pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on
reports of an excess of adverse events during the pre-and perinatal periods, the presence of
cognitive and behavioral signs during childhood and adolescence, and the lack of evidence
of a neurodegenerative process in most individuals with schizophrenia. 1 To date, studies of
the association between schizophrenia and genes coding for neurodevelopmental role has …
pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on
reports of an excess of adverse events during the pre-and perinatal periods, the presence of
cognitive and behavioral signs during childhood and adolescence, and the lack of evidence
of a neurodegenerative process in most individuals with schizophrenia. 1 To date, studies of
the association between schizophrenia and genes coding for neurodevelopmental role has …
SIR—Schizophrenia is a complex genetic disorder and has heritability of around 80%. The pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre-and perinatal periods, the presence of cognitive and behavioral signs during childhood and adolescence, and the lack of evidence of a neurodegenerative process in most individuals with schizophrenia. 1
To date, studies of the association between schizophrenia and genes coding for neurodevelopmental role has been published. 2 Recently, it has been reported that genetic variants around the gene neuregulin 1 (NRG1) are associated with schizophrenia in an Icelandic sample. 3 The replications of this finding have been reported independently from Scottish population4 and Caucasians born in UK and Ireland. 5 The at-risk haplotype was found to be over-represented in schizophrenics compared to controls.
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