Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
G Kirov, D Ivanov, NM Williams, A Preece, I Nikolov… - Biological …, 2004 - Elsevier
BACKGROUND: The gene encoding the dystrobrevin binding protein (DTNBP1) has been
implicated in the pathogenesis of schizophrenia by several association studies. We tried to
replicate these findings in a sample of 488 parent–proband trios recruited in Bulgaria.
Probands had a diagnosis of schizophrenia (n= 441) or schizoaffective disorder (n= 47).
METHODS: We genotyped eight single nucleotide polymorphisms within the gene, four of
which had been reported in previous studies, and four identified as informative by our group …
implicated in the pathogenesis of schizophrenia by several association studies. We tried to
replicate these findings in a sample of 488 parent–proband trios recruited in Bulgaria.
Probands had a diagnosis of schizophrenia (n= 441) or schizoaffective disorder (n= 47).
METHODS: We genotyped eight single nucleotide polymorphisms within the gene, four of
which had been reported in previous studies, and four identified as informative by our group …
