'I don't feel like a diabetic any more': the impact of stopping insulin in patients with maturity onset diabetes of the young following genetic testing
M Shepherd, AT Hattersley - Clinical medicine, 2004 - ncbi.nlm.nih.gov
Clinical medicine, 2004•ncbi.nlm.nih.gov
Hepatocyte nuclear factor-1 α (HNF-1 α) maturity onset diabetes of the young (MODY) is the
commonest cause of monogenic diabetes but is frequently misdiagnosed as type 1 diabetes.
The availability of genetic testing in MODY has improved diagnosis. Sulphonylurea
sensitivity in HNF-1 α patients means that those on insulin from diagnosis can transfer to
sulphonylureas and may improve glycaemic control. To gain insight into the implications for
patients of stopping insulin, in-depth interviews were conducted with eight HNF-1 α patients …
commonest cause of monogenic diabetes but is frequently misdiagnosed as type 1 diabetes.
The availability of genetic testing in MODY has improved diagnosis. Sulphonylurea
sensitivity in HNF-1 α patients means that those on insulin from diagnosis can transfer to
sulphonylureas and may improve glycaemic control. To gain insight into the implications for
patients of stopping insulin, in-depth interviews were conducted with eight HNF-1 α patients …
Abstract
Hepatocyte nuclear factor-1 α (HNF-1 α) maturity onset diabetes of the young (MODY) is the commonest cause of monogenic diabetes but is frequently misdiagnosed as type 1 diabetes. The availability of genetic testing in MODY has improved diagnosis. Sulphonylurea sensitivity in HNF-1 α patients means that those on insulin from diagnosis can transfer to sulphonylureas and may improve glycaemic control. To gain insight into the implications for patients of stopping insulin, in-depth interviews were conducted with eight HNF-1 α patients transferred to sulphonylureas after a median of 20 years on insulin. Thematic content analysis highlighted four key themes:
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