Genetic analysis of autoimmune type 1 diabetes mellitus in mice
JA Todd, TJ Aitman, RJ Cornall, S Ghosh, JRS Hall… - Nature, 1991 - nature.com
Nature, 1991•nature.com
Two genes, ldd-3 and ldd-4, that influence the onset of autoimmune type 1 diabetes in the
nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the
chromosome 17 major histocompatibility complex. A genetic map of the mouse genome,
analysed using the polymerase chain reaction, has been assembled specifically for the
study. On the basis of comparative maps of the mouse and human genomes, the homologue
of ldd-3 may reside on human chromosomes 1 or 4 and ldd-4 on chromosome 17.
nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the
chromosome 17 major histocompatibility complex. A genetic map of the mouse genome,
analysed using the polymerase chain reaction, has been assembled specifically for the
study. On the basis of comparative maps of the mouse and human genomes, the homologue
of ldd-3 may reside on human chromosomes 1 or 4 and ldd-4 on chromosome 17.
Abstract
Two genes, ldd-3 and ldd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of ldd-3 may reside on human chromosomes 1 or 4 and ldd-4 on chromosome 17.
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