[HTML][HTML] Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations
F Basso, L Freeman, CL Knapper, A Remaley… - Journal of lipid …, 2003 - ASBMB
The current model for reverse cholesterol transport proposes that HDL transports excess
cholesterol derived primarily from peripheral cells to the liver for removal. However, recent
studies in ABCA1 transgenic mice suggest that the liver itself may be a major source of HDL
cholesterol (HDL-C). To directly investigate the hepatic contribution to plasma HDL-C levels,
we generated an adenovirus (rABCA1-GFP-AdV) that targets expression of mouse ABCA1-
GFP in vivo to the liver. Compared with mice injected with control AdV, infusion of rABCA1 …
cholesterol derived primarily from peripheral cells to the liver for removal. However, recent
studies in ABCA1 transgenic mice suggest that the liver itself may be a major source of HDL
cholesterol (HDL-C). To directly investigate the hepatic contribution to plasma HDL-C levels,
we generated an adenovirus (rABCA1-GFP-AdV) that targets expression of mouse ABCA1-
GFP in vivo to the liver. Compared with mice injected with control AdV, infusion of rABCA1 …
